Malonate inhibition of oxidations in the Krebs tricarboxylic acid cycle.
نویسندگان
چکیده
The inhibition of succinate oxidation by malonate is a well known phenomenon. Since the oxidation of succinate to fumarate is an integral part of the Krebs cycle of oxidations, it has been generally assumed that the inhibitory effect of malonate upon the oxidation of any member of the cycle is the result of the inhibition of the succinate to fumarate step. However, the present paper provides evidence that malonate inhibits oxidations in the cycle by at least two mechanisms: in addition to the inhibition resulting from a block of succinate oxidation, malonate inhibits oxidation by another mechanism that is believed to involve combination with magnesium ions.
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عنوان ژورنال:
- The Journal of biological chemistry
دوره 178 1 شماره
صفحات -
تاریخ انتشار 1949